A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men

Abstract

This study assessed associations between the CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study of 234 MI patients and 248 controls genotyped for 5 single-nucleotide polymorphisms (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200). For men, G allele frequency of rs2108622 and frequency of the T-C-G haplotype were significantly higher, and frequency of the T-C-A haplotype was significantly lower for MI patients than for controls (P = 0.006, P = 0.001 and P = 0.002, respectively). © 2008 Elsevier Inc. All rights reserved.