Split-Face Comparison of Two Hyaluronic Acid Fillers: Intersection of Rheology and Tissue Behavior in Midface Rejuvenation

Abstract

DOI: 10.1093/asjof/ojaf006; Aesthetic Surgery Journal Open Forum, 7, 1, 2025-01-17.; Abstract: Background: Hyaluronic acid (HA) fillers are one of the most popular aesthetic treatments for midface volumization, achieving optimal aesthetic improvements. Given the variety of HA filler products available, it is important for injectors to understand how their rheological properties can influence behavior in tissues. Objectives: To evaluate and compare (1) product integration and dynamic support and (2) lifting capacity of 2 rheologically different HA fillers (HA Contour [HACON] and HA Voluma [HAJVOL]) through ultrasound and clinical photography. Methods: Randomized, split-face study (n = 11) comparing 2 midface HA fillers over a 12-month period with initial injection along the zygomatic arch at Day 0 and optional touch-up at Month 1. Eligible patients were aged 22 to 65 years with midface volume loss and contour deficiency. Assessments included ultrasound (neutral and smiling), clinical