P-328 Which is the best first approach for liver-only synchronic metastasis rectal cancer?

Abstract

posters P À 328 Which is the best first approach for liver-only synchronic metastasis rectal cancer? Introduction: Approximately 10% of patients (p) with rectal cancer have synchronic liver-only metastasis (RCSLM). Although local and systemic therapies are required for this setting, there is not a well defined sequence of treatments. We previously reported the analysis of both, the initial systemic and local approaches at a single institution. Now we present the analysis data of two institutions Methods: We retrospectively reviewed the medical records of RCSLM p between Jan 2005 and Jan 2014. The "first chemotherapy" (Ch) approach and the "first local" (Lo) approach (surgery or radiotherapy) were reviewed in terms of patient characteristics, tumour features and survival. Results: Seventy-four p (43 men) with a median age of 64 years old (35-88) and ECOG 0-1 (88%) were analyzed. Most (80%) of the 51 p with known K-Ras status had wild-type. Thirty-nine p (53%) had bilobar liver metastasis (LM) with a median number LM of 3 and a median size of 2.9 cm for the largest lesion. Fifty-two p (70%) were treated with curative intention and, liver and rectal resections (LRR) were performed for 43p (58%). Basal CEA > 10.5 (p = 0.05), largest LM size (p = 0.04),