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Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways

Communications Biology (2021) 4(1)
DOI: 10.1038/s42003-020-01557-1
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Abstract

Myelin destruction and oligodendrocyte (OL) death consequent to metabolic stress is a feature of CNS disorders across the age spectrum. Using cells derived from surgically resected tissue, we demonstrate that young (

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Fernandes, M. G. F., Luo, J. X. X., Cui, Q. L., Perlman, K., Pernin, F., Yaqubi, M., … Antel, J. P. (2021). Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways. Communications Biology, 4(1). https://doi.org/10.1038/s42003-020-01557-1

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