Comparative study between the effect of Momordica charantia (wild and hybrid variety) on hypoglycemic and hypolipidemic activity of alloxan induced type 2 diabetic long-evans rats

Abstract

This study was undertaken to evaluate the hy- poglycemic and hypolipidemic effect of Momor- dica charantia (wild and hybrid variety) powder on alloxan induced type 2 diabetic male Long- Evans rats. Oral feeding of the M. charantia pow- der slightly decreased serum total cholesterol, triglyceride levels and LDL-cholesterol compared with wild, hybrid and standard drug. M. charan- tia wild variety showed more significant (p < 0.05, 0.01, 0.001) effect on blood glucose level when compared with hybrid variety and standard drug (glibenclamide, 5 mg/kg). At the same time rats’ serum insulin level markedly increased, wild variety showed more significant (p < 0.05, 0.01, 0.001) than glibenclamide control group and hybrid group. But M. charantia did not show any significant effect on HDL-cholesterol and liver glycogen. Thus, results of the study prove that the wild variety of M. charantia fruit have potent antidiabetic and antilipidemic property.