The flossing-dementia connection: A comprehensive review of the relationship between oral health practices and cognitive decline

Abstract

Dementia is a growing global health concern, with significant social and economic implications. As the search for preventive strategies intensifies, recent studies have investigated the potential association between oral health, particularly flossing, and the risk of developing dementia. This review aims to critically analyze the existing evidence and explore potential mechanisms underlying the relationship between flossing and dementia. Various mechanisms have been proposed to explain the potential association. Poor oral health, including chronic periodontal disease and dental plaque accumulation, can lead to systemic inflammation and the release of pro-inflammatory cytokines, which may contribute to neuroinflammation and neuronal damage in the brain. Additionally, oral bacteria and their byproducts may enter the bloodstream and reach the brain, triggering immune responses and neurotoxicity. Flossing may help reduce oral bacteria and inflammation, thereby mitigating these potential pathways. Additionally, investigations focusing on the underlying mechanisms are crucial to understanding the potential pathways involved. Promoting good oral hygiene practices, including flossing, alongside comprehensive oral care, may have broader implications for brain health and cognitive well-being.