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New mechanism of chromatin compartmentalization by BRD2

Trends in Genetics
DOI: 10.1016/j.tig.2022.06.016
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Abstract

The molecular mechanism underlying 3D genome compartmentalization remains a mystery. Xie et al. found that the bromodomain and extraterminal (BET) family scaffold protein BRD2 promotes the compartmentalization of the accessible chromatin domains after cohesin loss. An antagonistic interplay between loop extrusion and compartmentalization modulates chromatin folding.

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APA

Cheng, Y., & Wang, S. (2022, December 1). New mechanism of chromatin compartmentalization by BRD2. Trends in Genetics. Elsevier Ltd. https://doi.org/10.1016/j.tig.2022.06.016

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