Clinical characteristics of tuberculosis in liver or heart transplant recipients

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Abstract

Background: Post-transplant tuberculosis (TB) is a serious complication in solid organ transplant recipients worldwide, However there is little or no data on TB in liver or heart transplant recipients in Korea. Methods: The incidence and clinical characteristics of TB of 730 patients who had undergone a liver transplant in a university hospital in Korea between 1992 and 2004, and 110 heart transplant recipients in the same period, were reviewed retrospectively. Results: The incidence of TB was 1.5%(11/730) and 2.7%(3/110) in the liver and heart transplantation, respectively. The median time from the transplant to the development of TB was 8.4 months(1.0-30.8). and the mean time from the symptoms to the diagnosis of TB was 2.1±3.6 months(0.3-13.2). Nine patients (65%) had pulmonary TB and five (35%) had extrapulmonary TB. The leukopenia and positive HbeAg at the baseline, post-transplant diabetes mellitus, and chronic rejection were associated with the development of TB in the liver transplant recipients. Ten patients were treated with a 4-drug standard regimen for a mean duration of 7.8±3.5 months. One patients died of TB. Conclusion: The incidence of TB in liver or heart transplant recipients was similar to that reported in other countries with a similar TB-burden.

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APA

Jung, H., Oh, Y. M., Sang, D. L., Woo, S. K., Dong, S. K., Won, D. K., … Tae, S. S. (2006). Clinical characteristics of tuberculosis in liver or heart transplant recipients. Tuberculosis and Respiratory Diseases, 61(5), 440–446. https://doi.org/10.4046/trd.2006.61.5.440

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