Aza-Diels-Alder Reaction: An Efficient Approach for Construction of Heterocycles

Abstract

A review. Aza heterocycles comprise some rousing structures in biol. systems. The aza-Diels-Alder reaction is a [4π + 2π] cycloaddn., involving a nitrogen atom in either diene or dienophile or both for the generation of unsatd. N-hexacycles. Although aza-Diels-Alder reaction has made a wonderful journey through different stages of development it is still considered as one of the hot topics of research because of procedural simplicity, high atom economy, regio- and stereoselectivity. Building blocks of many pharmaceutically as well as pharmacol. vital heterocycles have come out as a result of application of aza-Diels-Alder protocol in numerous chem. reactions. This review article describes the state of the art of the aza-Diels-Alder reactions highlighting some of the very first discovery of this pericyclic reaction to most important modern developments. This discussion is highly focused on awesome versions of aza-Diels-Alder reaction under selected and magnificent catalytic systems and provides an overview on versatility of this special branch of Diels-Alder reaction towards the creation of a flood of N-contg. mols. [on SciFinder(R)]