Evaluation of Antidiabetic Activity of Polyherbal Formulation in Streptozotocin-Induced Diabetic Rats

Abstract

This study was undertaken to evaluate the antidiabetic effect of polyherbal formulation containing varied concentration of Phyllanthus emblica and Annona squamosa leaves extract in streptozotocin induced type 2 diabetic rats. The polyherbal formulation (HF1 and HF2) were administered orally in Streptozotocin-induced diabetic rats. After the administration of polyherbal formulation, blood glucose levels were monitored at specific intervals and it was found that they were significant lowered. The effect of polyherbal formualtion on induced hyperlipidemia was analyzed where the fraction significantly lowered the elevated total cholesterol, triglycerides (TGL) and low density lipoprotein (LDL) level while increased the High density lipoprotein (HDL). Glibenclamide was used as a standard drug at a dose of 0.50 mg/kg body weight. The outcomes of results exhibited that HF2 has significant antidiabetic activity in streptozotocin-induced rats compared to HF1.