Correlation between improve lung function with decrease of eosinophil levels in atopic asthma persistent after asthma exercise

Abstract

Background: Asthma is a chronic inflammation that is a serious health problem in the world, especiallyin developing countries, one of which is characterized by limited expiratory airflow. Expiratory limitations in asthma patients due to respiratory obstruction asthma exercise. Spirometry is the gold standard for identifying obstruction in asthmatic. The high eosinophils are one marker of allergies. One of the non-pharmacological management of asthma. Objectives: The purpose of this study was to analyze the correlations between Forced Exhaled Volume in the first 1 second (FEV1), Forced Vital Capacity (FVC) and FEV1/FVC ratio with eosinophil levels in persistent atopic asthma Method: The design of this study was an experiment with a sample of 39 people. Measurements of FEV1, FVC and FEV1/FVC ratio measured by spirometry H-101 and eosinophils were carried out in 2 methods namely manual and automatic. The manual procedure used eosin staining and automatically used hematology analyzer. Asthma exercises are carried out 4 times a week for 8 weeks. Statistical analysis used the Spearman test Results: The correlation between FEV1 and eosinophil levels -0,379 with a value of 0.037; there was a correlation between FVC and eosinophils -0.462 with a value of 0.001; there was a correlation of FEV1/FVC -0.403 with eosinophils a value of 0.028 Conclusion: There was a correlation between improvement in pulmonary function with a decrease in eosinophil levels after following asthma exercises in persistent atopic asthma.