Development of Nickel(II) Thiosemicarbazone Complexes as Potential Antibacterial Agents: Microwave Assisted Synthesis, Spectral Characterization and Antibacterial Studies

Abstract

Some novel Nickel(II) aryl thiosemicarbazone complexes with the formula [Ni(LIGAND-1)2(NO3)2], [Ni(LIGAND-2)2(NO3)2], [Ni(LIGAND-3)2(NO3)2], and [Ni(LIGAND-4) 2(NO3)2] have been successfully synthesized. LIGAND-1 corresponds to 4-Phenyl-3-buten-2-one thiosemicarbazone (PBTSC), LIGAND-2 is 4-Hydroxy-3-methylbenzaldehyde thiosemicarbazone (HMBTSC), LIGAND-3 refers to 4-Methoxybenzaldehyde thiosemicarbazone (MBTSC), and LIGAND-4 represents Propiophenone thiosemicarbazone (PTSC). The Ligands were synthesized by reacting thiosemicarbazide with substituted aromatic aldehydes and ketones using microwave irradiation. Nickel(II) ions were subsequently complexed with the Ligands to produce the final complexes. FTIR, UV-visible spectroscopy, along with elemental analysis were used to characterize produced compounds. Additionally, antibacterial activity of ligands and their analogous nickel (II) complexes was established.