An overview about Therapeutic uses, clinical efficacy, safety and classes of Retinoids and its efficacy for Treatment of skin aging

Abstract

Abstract                                                                                                                                                     Skin aging has both underlying and extraneous  factors. the outermost organ of the human body, the skin suffers from environmental damage to agents such as air pollution and cigarette smoking, the resulting skin aging is called extraneous aging, which is also known as photoaging or the exposure to sunlight via UV radiation. Retinoid  refers to the synthetic and natural analogues of vitamin A. Retinoids  are a class of compounds derived from vitamin A or showing structural and/or functional similarities to vitamin A. Retinoids as dermatological agents that are widely applied in cosmetics and effective against acne, psoriasis, skin aging, and other skin conditions. Their  susceptibility to degradation is a limiting factor for their widespread use, In other words; retinoid concentration in cosmetics is restricted, and one particular form–retinoic acid, is banned due to safety reasons. These include retinol, retinal, tretinoin (retinoic acid), isotretinoin, and alitretinoin, etretinate, adapalene, bexarotene, tazarotene, and Trifarotene.  The aim of this review is to introduce  the different uses of different types of retinoid in cosmetic and dermatological treatments. Key words:  Retinoids, skin, photoaging, vitamin A