Glomerular hyperfiltration during the onset of diabetes mellitus in two strains of diabetic mice (C57BL/6J db/db and C57BL/KsJ db/db)

Abstract

GFR estimated by the total clearence of51Cr-EDTA increases from 41 to 60 ml/min·m2 at the onset and during the development of marked hyperglycaemia and obesity in female diabetic mice (db/db) of the C57BL/6J and the C57BL/KsJ strains (blood sugar rises from 160 to 400 mg/100 ml). GFR decreases slowly in older diabetic mice (>120 days old) approaching the control values (42±7 ml/ min·m2) and then decreases still further. The total clearance of14C-hippuric acid is unaltered in db/db mice and controls between 45 and 150 days of age (96±20 ml/min·m2). This suggests no alteration of RPF during the development of the diabetic syndrome. The glomerular hyperfiltration of diabetic mice lasts until they are 120 days old and shows no correlation with the different blood glucose levels typical for diabetic mice (db/db) of the two strains. © 1978 Springer-Verlag.