Hepatoprotective and haematoprotective roles of gongronema latifolium benth aqueous extract in alloxaninduced diabetic rats

Abstract

This research evaluates the hepatoprotective and haematoprotective abilities of the extract of Gongronema latifolium leaves in diabetic rats. Forty animals were induced intraperitoneal using alloxan of 150 mg/kg body weight. The Wistar rats were thereafter divided as follows: normal control, diabetic untreated control, diabetic rats received 5 mg/kg body weight of metformin, and diabetic rats received three ethnobotanical doses (6.36, 12.72, and 25.44 mg/kg body weight) of aqueous extract of G. latifolium leaves (AEGLL). On the 14th day of the experiment, the rats were relinquished, and various hepatoprotective and haematoprotective biomarkers were assessed. Diabetic rats administered AGELL demonstrated normoglycaemia, reduced inflammatory levels as well as activities of transaminases. Also, diabetic animals that received AGELL show a substantial increase in protein, albumin, and hematological parameters determined when linked to diabetic control rats. Hence, three ethnobotanical doses revealed the hepatoprotective and haematoprotective nature of this plant.