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High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia

OncoImmunology (2018) 7(8)
DOI: 10.1080/2162402X.2018.1465167
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Abstract

In this study, we extensively dissected the phenotypic complexity of the splenic tumor microenvironment (TME) in chronic lymphocytic leukemia (CLL) by high-dimensional mass cytometry (CyTOF). As a result, we identified potential new targets and tested a dual immune checkpoint blockade targeting the TME in pre-clinical mouse models of CLL.

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Wierz, M., Janji, B., Berchem, G., Moussay, E., & Paggetti, J. (2018). High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia. OncoImmunology, 7(8). https://doi.org/10.1080/2162402X.2018.1465167

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