A simple, efficient and general procedure for acetalization of carbonyl compounds and deprotection of acetals under the catalysis of indium(III) chloride

Abstract

Indium (III) chloride efficiently catalyzes the protection of a variety of aldehydes and ketones to their corresponding 1,3-dioxolanes and dialkyl acetals in refluxing cyclohexane. On the other hand, deprotection of acetals is also achieved in refluxing aqueous methanol under the catalysis of indium(III) chloride.