Abstract
In this article, Schmidt and colleagues show that differentiating human NSCs in co-culture with microglia enhance dopaminergic differentiation. The effect is consistent across different NSC and microglial cell lines but restricted to microglia of embryonic origin. TNFα, IL-1β, and IGF1 are identified as key mediators of the effect, providing new insights into factors stimulating dopaminergic differentiation.
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Schmidt, S. I., Bogetofte, H., Ritter, L., Agergaard, J. B., Hammerich, D., Kabiljagic, A. A., … Meyer, M. (2021). Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells. Stem Cell Reports, 16(2), 281–294. https://doi.org/10.1016/j.stemcr.2020.12.011
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