Penetration of sulbactam and ampicillin into cerebrospinal fluid of infants and young children with meningitis

Abstract

Infusions of 50 mg of sulbactam per kg per day and 400 mg of ampicillin per kg per day in divided doses to infants and children with bacterial meningitis produced levels in cerebrospinal fluid approximately one-third those in serum. Concentrations in cerebrospinal fluid of 5.5 μg of sulbactam per m and 16.0 μg of ampicillin per ml declined within a few days of therapy to 1.9 μg of sulbactam per ml and 5.2 μg of ampicillin per ml.