Hydrazonoyl chlorides in the synthesis of pyrazolo[5,1-c][1,2,4]triazole derivatives and their biological activities

Abstract

A new series of 7-arylazopyrazolo[5,1-c][1,2,4]triazoles was synthesised via reaction of 3-amino-4-(arylhydrazono)-4,5-dihydropyrazol-5-ones with hydrazonoyl halides using triethylamine as a basic catalyst. The structure of all the synthesised compounds was confirmed on the basis of elemental and spectral analyses. Moreover, the antimicrobial and antitumour activities of these compounds were evaluated and the results obtained indicate the weak efficacy of some of them as antibacterial agents. However, the results of antitumour activity against HepG-2 liver cancer and HCT-116 colon cancer of some derivatives showed good activity in comparison with the reference drugs.