Contralateral bulla neogenesis associated with postoperative recurrences of primary spontaneous pneumothorax in young patients

Abstract

Background: Video-assisted thoracoscopic surgery (VATS) is considered an acceptable treatment for recurrent primary spontaneous pneumothorax (PSP). However, recent reports have described a high postoperative recurrence rate in young patients with PSP. We hypothesized that ineffective VATS may have been performed for these patients (aged <25 years). We evaluated the factors preventing postoperative recurrence in young PSP patients in order to identify patients with effective surgery. Methods: Between April 2009 and December 2018, we retrospectively evaluated 92 patients aged <25 years who underwent first VATS bullectomy for PSP. Factors such as gender, smoking habit, history of contralateral PSP, family history, body mass index (BMI), and contralateral bulla neogenesis on high-resolution computed tomography were evaluated. Results: The mean BMI was 18.8±1.8. Contralateral bulla neogenesis was present in 31 patients (33.7%). The median period of observation for postoperative recurrence was 401.5 days. Thirty cases (32.6%) developed postoperative recurrence. Univariate and multivariable analyses showed that a BMI ≥18.0 and no contralateral bulla neogenesis were significant factors preventing postoperative recurrence (P=0.018, hazard ratio: 0.41 and P=0.0046, hazard ratio: 0.25, respectively). Conclusions: Although the patients aged <25 years have a high rate of postoperative recurrence, the patients with BMI ≥18.0 and no contralateral bulla neogenesis have a significantly lower rate of postoperative recurrence rate.