Network pharmacology databases for traditional Chinese medicine: Review and assessment

876Citations
Citations of this article
476Readers
Mendeley users who have this article in their library.

Abstract

The research field of systems biology has greatly advanced and, as a result, the concept of network pharmacology has been developed. This advancement, in turn, has shifted the paradigm from a “one-target, one-drug” mode to a “network-target, multiple-component-therapeutics” mode. Network pharmacology is more effective for establishing a “compound-protein/gene-disease” network and revealing the regulation principles of small molecules in a high-throughput manner. This approach makes it very powerful for the analysis of drug combinations, especially Traditional Chinese Medicine (TCM) preparations. In this work, we first summarized the databases and tools currently used for TCM research. Second, we focused on several representative applications of network pharmacology for TCM research, including studies on TCM compatibility, TCM target prediction, and TCM network toxicology research. Third, we compared the general statistics of several current TCM databases and evaluated and compared the search results of these databases based on 10 famous herbs. In summary, network pharmacology is a rational approach for TCM studies, and with the development of TCM research, powerful and comprehensive TCM databases have emerged but need further improvements. Additionally, given that several diseases could be treated by TCMs, with the mediation of gut microbiota, future studies should focus on both the microbiome and TCMs to better understand and treat microbiome-related diseases.

References Powered by Scopus

Cytoscape: A software Environment for integrated models of biomolecular interaction networks

35075Citations
N/AReaders
Get full text

STRING v10: Protein-protein interaction networks, integrated over the tree of life

8087Citations
N/AReaders
Get full text

TCMSP: A database of systems pharmacology for drug discovery from herbal medicines

3796Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula

343Citations
N/AReaders
Get full text

Applications of Network Pharmacology in Traditional Chinese Medicine Research

270Citations
N/AReaders
Get full text

Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

242Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Zhang, R., Zhu, X., Bai, H., & Ning, K. (2019). Network pharmacology databases for traditional Chinese medicine: Review and assessment. Frontiers in Pharmacology. Frontiers Media S.A. https://doi.org/10.3389/fphar.2019.00123

Readers over time

‘19‘20‘21‘22‘23‘24‘25050100150200

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 104

63%

Researcher 29

18%

Professor / Associate Prof. 17

10%

Lecturer / Post doc 14

9%

Readers' Discipline

Tooltip

Pharmacology, Toxicology and Pharmaceut... 47

34%

Biochemistry, Genetics and Molecular Bi... 47

34%

Agricultural and Biological Sciences 28

20%

Medicine and Dentistry 16

12%

Article Metrics

Tooltip
Mentions
News Mentions: 6
Social Media
Shares, Likes & Comments: 13

Save time finding and organizing research with Mendeley

Sign up for free
0