Expression of microRNA-3133 correlates with the prognosis in patients with clear cell renal cell carcinoma

Abstract

Clear cell renal cell carcinoma (ccRCC) represents a prevalent urological malignancy among men worldwide. MicroRNAs (miRNAs) are involved in the progression of diverse human cancers. The aim of this study was to explore the expression profile and prognostic value of microRNA-3133 (miR-3133) in ccRCC.The expression of miR-3133 in ccRCC tissues and non-cancerous tissues was measured by quantitative real-time polymerase chain reaction (qRT-PCR). Chi-square test was applied to evaluate the relationship between miR-3133 expression and clinical characteristics. Overall survival curve was constructed by Kaplan-Meier with log-rank test. The prognostic value of miR-3133 in ccRCC was estimated by Cox regression analysis.MiR-3133 was downregulated in ccRCC samples compared to the matched noncancerous samples (P