Atypical megakaryocytes in preleukemic phase of acute myeloid leukemia

Abstract

Mono and binucleated megakaryocytes appeared in the bone marrow of a 6 yr old white male 9 mth prior to the development of acute myeloid leukemia; in addition, leukopenia and anemia antedated the diagnosis by 3.5 and 9 mth, respectively. The report suggests that mono and binucleated megakaryocytes may be a useful diagnostic finding in early leukemia.