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Interaction of qinghaosu (artemisinin) with cysteine sulfhydryl mediated by traces of non-heme iron

Angewandte Chemie - International Edition (1999) 38(17) 2580-2582
DOI: 10.1002/(SICI)1521-3773(19990903)38:17<2580::AID-ANIE2580>3.0.CO;2-J
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Abstract

The antimalarial action of 1,2,4-trioxanes such as qinghaosu (QHS) may take place through the mechanism shown schematically: In the presence of cysteine traces of non-heme iron (FeSO4) may cleave the peroxy bond of QHS rapidly, and the transient carbon-centered radical can attack the sulfur ligand to form a covalent bond.

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Wu, Y., Yue, Z. Y., & Wu, Y. L. (1999). Interaction of qinghaosu (artemisinin) with cysteine sulfhydryl mediated by traces of non-heme iron. Angewandte Chemie - International Edition, 38(17), 2580–2582. https://doi.org/10.1002/(SICI)1521-3773(19990903)38:17<2580::AID-ANIE2580>3.0.CO;2-J

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