Electrical properties of chemoreceptor elements in the carotid body

Abstract

The electrical properties of chemoreceptor afferent nerve fibers and glomus cells and the behavior of cytosolic Ca2+ in glomus cells are reviewed. While this has not been confirmed, spontaneously depolarizing potentials (SDPs) recorded in a chemoreceptor afferent terminal may be the postsynaptic expression of presynaptic events. Glomus cells, which are presynaptic elements, either depolarized or hyperpolarized in response to natural and chemical stimulation. Afterhyperpolarization following an initial depolarization and after-depolarization following an initial hyperpolarization were often seen. When a glomus cell depolarizes, voltage noise increases despite a decrease in input resistance in both intact and denervated carotid bodies. The voltage noise may be "receptor noise" generated in the glomus cell itself. The electrical properties of glomus cells change in the denervated carotid body, which suggests that the chemoreceptor afferent nerve exerts some trophic effect(s) on glomus cells. Hypoxia either increases or decreases cytosolic Ca2+, while ACh or NaCN induces either an increase or no change in cytosolic Ca2+ in glomus cells. There are at least two possible explanations for voltage changes in glomus cells: a chemical stimulus first depolarizes the glomus cell and induces Ca2+ influx to release chemical substances, or a chemical stimulus induces an increase in [Ca2+]i and then hyperpolarizes the glomus cell via potassium influx. © 2002 Wiley-Liss, Inc.