Changes in ciprofloxacin resistance levels in Enterobacter aerogenes isolates associated with variable expression of the aac(6′)-Ib-cr gene

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Abstract

Two closely related Enterobacter aerogenes isolates presented a new identical aac(6′)-Ib-cr genetic environment, including IS26. One isolate showed lower MICs of ciprofloxacin, norfloxacin, tobramycin, and amikacin and decreased expression of aac(6′)-Ibcr, which might be related to a 12-bp deletion causing a displacement of the -10 box upstream of the aac(6′)-Ib-cr gene. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

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Ruiz, E., Ocampo-Sosa, A. A., Alcoba-Flórez, J., Román, E., Arlet, G., Torres, C., & Martínez-Martínez, L. (2012). Changes in ciprofloxacin resistance levels in Enterobacter aerogenes isolates associated with variable expression of the aac(6′)-Ib-cr gene. Antimicrobial Agents and Chemotherapy, 56(2), 1097–1100. https://doi.org/10.1128/AAC.05074-11

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