Abstract
Four new antibiotics, TMC-171A (2), B (3), C (4) and TMC-154 (5) have been isolated from the fermentation of fungal strains Gliocladium sp. TC 1304 and TC 1282, respectively. Spectroscopic and degradation studies have shown that TMC-171s and TMC-154 were new members of the TMC-151 class of antibiotics, unique polyketides modified with a D-mannose and a D-mannitol or a D-arabitol. These compounds showed moderate cytotoxicity to various tumor cell lines.
Cite
CITATION STYLE
Kohno, J., Asai, Y., Nishio, M., Sakurai, M., Kawano, K., Hiramatsu, H., … Komatsubara, S. (1999). TMC-171A, B, C and TMC-154, novel polyketide antibiotics produced by Gliocladium sp. TC 1304 and TC 1282. Journal of Antibiotics, 52(12), 1114–1123. https://doi.org/10.7164/antibiotics.52.1114
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
