Antihyperlipidemic And Glucose Lowering Effect Of Extract Of Bioregulator Treated Okra (Abelmoschus Esculentus L.) Fruits in Triton-Induced Hyperlipidemia Rats

Abstract

Extracts from okra have been used to alleviate not only hyperglycemia but also hyperlipidemia in diabetic mice induced by alloxan and streptozocin. However, its hypolipidemic activity has not yet been clearly studied. This study was aimed to study the antihyperlipidemic potential of bioregulator treated okra fruit in triton-X induced hyperlipidemic rats. Hyperlipidemia was induced in rats by administration of triton-X (100mg/kg i.p.). After 14 days of induction, hyperlipidemic rats received AWB (okra extract treated with bioregulator, AWOB (okra extract without bioregulator) and atorvastatin up to 28 days. The extracts activities were assessed on serum blood glucose, lipid profiles, carbohydrate enzymes, antioxidant and non-enzymes antioxidant enzymes, malondialdehyde level, and HMG-CoA reductase activity of control and drug-treated rats. The extract exhibited a strong dose-dependent antihyperlipidemic activity and at dose level 400mg/kg (AWB) p.o. the extract showed a significant (P≤0.05) decrease in blood glucose, TC, TG, LDL, VLDL, MDA, gluconeogenic enzymes and significant (P≤0.05) increase in HDL-C, glycogenic enzymes, antioxidant enzymes and non-enzymes antioxidant in a dose-dependent manner comparing with standard atorvastatin-treated group. The present study demonstrated that the extract of bioregulator treated okra exhibits a potent lipid lowering activity and well compared with the atorvastatin than extract without bioregulator.