Anomalous Gene Expression in Alzheimer Disease: Cause or Effect

Abstract

Altered chromatin conformation and increased amounts of aluminum have been observed in the brains of patients with Alzheimer disease. These factors have been shown to affect gene regulation. In this report, we describe how these changes may selectively alter the pool size of the human light chain neurofilament gene and play a fundamental role in the expression of this disease. © 1991, Canadian Neurological Sciences Federation. All rights reserved.