PP85. CAVERNOMA AS A BENIGN VASCULAR MALFORMTION: IS IT TIME FOR A RETHINK?

Abstract

INTRODUCTION: Rapid growth in cerebral cavernous malformation is rare. We present the case of a 71 year old patient with known multiple cavernomas over many years in whom one lesion showed rapid expansion in size. Histological examination revealed co-existence of glioblastoma within the cavernoma. We review the literature for similar cases and discuss the potential mechanisms underlying this transformation. METHODS: Review of the literature though databases MEDLINE, EMBASE, PubMed and Google scholar was performed using keywords glioma, cavernoma and collision tumour. RESULTS: Three cases were identified in the literature with known cerebral cavernous malformations that transformed to glioblastoma multiforme. All cases were female with imaging confirming rapid growth in the lesion. CONCLUSION: Although rare, rapid expansion of existing cavernoma should be treated as suspicious for transformation into other tumour types.