Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells

Abstract

Background: The function, localization, and processing of the amyloid precursor protein (APP) is regulated by phosphorylation. Results: Copper promotes APP trafficking by phosphorylation at threonine 668 in SH-SY5Y cells. Conclusion: By promoting APP phosphorylation, copper regulates its intracellular localization. Significance: Understanding the role copper plays in regulating APP function in normal neuronal cells will provide insight into the interplay between copper and APP in normal and pathological conditions. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.