Abstract
Longer is better: PolytheonamideB, the largest nonribosomal linear peptide identified to date, is a transmembrane channel-forming peptide. Nine of its substructures have now been chemically synthesized. The membrane-disrupting and ion-channel-forming sequences as well as the cytotoxicity-enhancing sequence have been identified. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Matsuoka, S., Shinohara, N., Takahashi, T., Iida, M., & Inoue, M. (2011). Functional analysis of synthetic substructures of polytheonamide B: A transmembrane channel-forming peptide. Angewandte Chemie - International Edition, 50(21), 4879–4883. https://doi.org/10.1002/anie.201101533
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