Infarct Diameter for Predicting Cognitive Dysfunction inIschemic Stroke Survivors in West Nusa Tenggara, Indonesia

Abstract

Cognitive dysfunction is an important consequence of ischemic stroke, which can progress in the first few years and is primarily determined by clinical factors. This study aimed to investigate the clinical determinants of cognitive dysfunction in stroke survivors in West Nusa Tenggara Province, Indonesia. This cross-sectional study assessed 255 ischemic stroke survivors with a mean age of 57.1±9.3 years old and 29-79 years old, recruited consecutively in three mainhospitals in West Nusa Tenggara Province between March 2019 and October 2021. Categorical data collected included age, sex, education level, clinicaldeterminants of ischemic stroke, and cognitive status of the patients. The association between the clinical determinants of ischemic stroke and the risk ofcognitive dysfunction in patients was analyzed using logistic regression after adjusting for age, sex, and level of education. The final multiple logistic regressionanalysis models revealed infarct diameter as the only clinical determinant significantly associated with an increased risk of cognitive dysfunction (OR = 3.14;95% CI = 1.20-8.23). Thus, a larger infarct diameter is the only clinical determinant of cognitive dysfunction in ischemic stroke survivors in West NusaTenggara Province, Indonesia.