Abstract
A novel New Delhi metallo-β-lactamase, NDM-13, was identified in a carbapenem-resistant Escherichia coli clinical isolate obtained from the urine of a patient in Nepal. The enzymatic activity of NDM-13 against β-lactams was similar to that of NDM-1. However, NDM-13 displayed significantly higher kcat/Km ratios for cefotaxime. The genetic environment of blaNDM-13 was determined to be tnpA-IS30-blaNDM-13-bleMBL-trpF-dsbC-cutA-groES-groL, with blaNDM-13 located within the chromosome.
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CITATION STYLE
Shrestha, B., Tada, T., Miyoshi-Akiyama, T., Shimada, K., Ohara, H., Kirikae, T., & Pokhrel, B. M. (2015). Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal. Antimicrobial Agents and Chemotherapy, 59(9), 5847–5850. https://doi.org/10.1128/AAC.00332-15
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