Digit ratio (2D:4D): A Potential Anatomical Biomarker for Predicting the risk of development of Polycystic Ovarian Syndrome

Abstract

Introduction: Variable exposure to prenatal androgens may be responsible for the spectrum of endocrine and metabolic disturbances characteristic of Polycystic ovarian syndrome. Perinatal androgen level has been proved to play pivotal role in establishing finger lengths in foetus. It has been suggested that the 2D:4D ratio is a negative correlate of prenatal testosterone and a positive correlate of prenatal estrogens. Once established in early neonatal life digit ratio assumed to be stable in later life. Aims: To find out any possible association between digit ratio and developing PCOS Methodology: 400 females (200 cases and 200 controls) of age group 18-40 were studied. The length of the index (2D) and ring finger (4D) were measured and 2D:4D ratio were calculated and statistically analyzed. Results: There was a significant difference (p<0.0001) in 2D:4D ratio between women with PCOS and the control group. Also 2D:4D relationship is strong for right hand. Conclusion: This anatomical expression can be used as a tool for early prediction of PCOS and hence substantiates the need for lifestyle modification to counteract this syndrome at its nascent stage Keywords: