Rhodium-catalyzed oxidative olefination of C-H Bonds in Acetophenones and Benzamides

Abstract

A good neighborhood! The metal-catalyzed oxidative C-H functionalization of electron-rich arenes is well-established, but analogous reactions of electron-poor substrates are rare. A new application makes use of common electron-withdrawing functional groups (COMe, CONH2, CONEt 2) in the rhodium-catalyzed oxidative Heck reaction to generate complex organic molecules. Cp= η5-C5Me 5. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.