DNA-based hydrolytic kinetic resolution of epoxides

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Abstract

DNA-bound copper(II) complexes serve as catalysts for the hydrolytic kinetic resolution of 2-pyridyloxiranes in water. Selectivity factors of up to 2.7 were achieved, indicating a chirality transfer of DNA to epoxides via a coordinated metal ion. © 2008 Elsevier Ltd. All rights reserved.

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Dijk, E. W., Feringa, B. L., & Roelfes, G. (2008). DNA-based hydrolytic kinetic resolution of epoxides. Tetrahedron Asymmetry, 19(20), 2374–2377. https://doi.org/10.1016/j.tetasy.2008.10.004

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