The effects of combination of antibiotic and antioxidants on haemato-biochemical parameters in dogs affected with gastroenteritis

Abstract

Gastroenteritis is one of the most prevalent problems in canine animal practice. In majority of the cases exact cause remain unclear so for treating such conditions symptomatic and supportive treatment plays vital role in therapy. Antioxidants have crucial role in the recovery of any disease condition, so keeping in mind these things present study was planned to see the effectiveness of incorporation of antioxidants in treatment regimen. For the study three different treatment trials were conducted with six dogs in each treatment group. All the dogs were treated with ceftriaxone-tazobactam along with antioxidants i.e. vitamin C and N-acetylcysteine in different combinations to assess their comparative effect on treatments. Haematological and biochemical parameters of affected dogs were compared with six healthy dogs on day 0, 3 and 5 of treatment trial. The gastroenteritis dogs showed haemo-concentration with increased packed cell volume, leukocytosis, neutrophilia with thrombocytopenia. Elevated liver and kidney function parameters along with decreased serum electrolytes were observed in all gastroenteritis dogs. The results of the study inferred that among all the three groups, group which was administered with both the antioxidants along with antibiotic showed better recovery than rest of the two groups.