Indium(III)-catalyzed synthesis of N-substituted pyrroles under solvent-free conditions

Abstract

A variety of N-substituted pyrroles have been synthesized by reacting γ-diketones (R1C(O) CH2CH2C(O)R 2: R1, R2 = Me, Ph) with amines (RNH 2: R=Alkyl, Aryl, TsNH) or diamines (1,6-diaminohexane and 1,2-diaminoethane) in the presence of indium tribromide, indium trichloride or indium trifluoromethanesulfonate at room temperature under solvent-free conditions. The experiment protocol features simple operations, and the products are isolated in high to excellent yields (81-98%). ©2008 Sociedade Brasileira de Química.