Neither cimetidine nor probenecid affect the pharmacokinetics of tenoxicam in normal volunteers.

Abstract

The effect of pretreatment with cimetidine (1 g day‐1, 7 days) and of probenecid (1 g twice daily, 4 days) on the pharmacokinetics of tenoxicam (single oral dose, 20 mg) was studied in six healthy volunteers. Cmax was increased significantly when tenoxicam was given with probenecid (2.8 micrograms ml‐1 alone, 3.5 micrograms ml‐1 after probenecid; P < 0.005). No other pharmacokinetic parameters were altered significantly by either drug. It is concluded that neither cimetidine nor probenecid affects the pharmacokinetics of tenoxicam in a clinically important way. 1994 The British Pharmacological Society