Genetic polymorphisms of cytochrome P450 19 and 1B1, alcohol use, and breast cancer risk in Korean women

Abstract

A case-control study was performed to assess the potential influence of CYP19 Arg264Cys and CYP1B1 Leu432Val polymorphisms on breast cancer risk in a series of Korean breast cancer patients and controls. The results suggest that the CYP19 Arg264Cys polymorphism modifies breast cancer risk (OR = 1.5, 95% CI = 1.1-2.2), especially in association with alcohol consumption (P for interaction = 0.04), whereas the CYP1B1 Leu432Val polymorphism appears to play no role here. © 2003 Cancer Research UK.