An association and meta-analysis study of 4 SNPs from beta-2 adrenergic receptor (ADRB2) gene with risk of asthma in children

Abstract

Background: Although various case-control studies have been conducted to investigate the relationship between ADRB2 gene polymorphisms and asthma risk in different population groups, the results have been conflicting and inconclusive. Objective: We performed a case-control study to investigate the association of 4 SNPs in the ADRB2 gene with risk of asthma in children, and then conducted a meta-analysis by combining the previous studies. Methods: A total of 340 patients and 340 agematched healthy controls were recruited. All of the subjects were genotyped using the PCRbased invader assay. The case-control study was performed to define the contribution of rs1042713, rs1042714, rs1800888, and rs1042711 to the predisposition of asthma. Additionally, we further conducted a meta-analysis of the study findings together with those of previously reported studies. Results: No significant association was found between the polymorphisms rs1042713, rs1042714, rs1800888, and rs1042711 and asthma in the current case-control study. The metaanalysis confirmed that there was no positive association of these SNPs with asthma in children in Asia, South America, Europe and the overall population. Conclusions: None of the four polymorphisms in ADRB2 gene were associated with a risk of asthma in a current children population.