Synthesis of 4-arylethyl-6-arylpyrimidine-2-thiols through aza-Michael addition/nucleophilic addition/aromatization tandem reactions

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Abstract

An efficient method for the synthesis of the title compounds by reactions of divinyl ketones with thiourea is described. This protocol has the advantages of high yields, mild reaction conditions and simple work-up procedure.

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Li, Z., Song, W., He, J., Du, Y., & Yang, J. (2018). Synthesis of 4-arylethyl-6-arylpyrimidine-2-thiols through aza-Michael addition/nucleophilic addition/aromatization tandem reactions. Heterocyclic Communications, 24(1), 23–26. https://doi.org/10.1515/hc-2017-0169

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