Microwave-assisted synthesis of unsymmetrical tetrapyrrolic compounds

Abstract

Unsymmetrical porphyrin, 5-(3-hydroxyphenyl)-10,15,20-tris-(4- carboxymethylphenyl)-21,23-H-porphine (TCMPOHM) and also the parent symmetrical compound 5,10,15,20-meso-tetrakis-(4-carboxymethylphenyl)-21,23H porphine (TCMP) were synthesized with superior yields using microwave irradiation. Structures were confirmed by 1H-NMR, 13C-NMR, UV-Vis and FTIR spectroscopy. Various NMR experimental approaches (including 13C-NMR, DEPT, COSY, HMBC and HMQC) were used to completely elucidate some interesting aspects concerning the structure of the new porphyrin compounds.