Dynamic Regulation of Host Restriction Factor Expression over the Course of HIV-1 Infection In Vivo

Abstract

In this study, we investigated the expression levels of host restriction factors in six untreated HIV-1-positive patients over the course of infection. We found that the host restriction factor gene expression profile consistently increased over time and was significantly associated with CD4 + T cell activation and viral load. Our data are among the first to demonstrate the dynamic nature of host restriction factors in vivo over time.