Evaluation of lipid profile and liver function in acute pancreatitis patients: A case control study

Abstract

Pancreatitis is described as any inflammation that manifests in acute or chronic forms in the pancreas. Acute pancreatitis is a sudden attack that leads to inflammation of the pancreas and affects the peripancreatic tissue and surrounding organ. In this study, liver function and lipid profile tests were evaluated in acute pancreatitis patients in order to find any relationship between liver function and lipid profile impairment and the etiology of acute pancreatitis. A total of 65 patients with acute pancreatitis, mean age 46.81 years, along with 65 healthy volunteers, mean age 43.06 years, were included in this study. Serum levels of T. protein, T. bilirubin, D. bilirubin, blood urea nitrogen, lipid profile, AST, ALT, and ALP were determined and statistical analysis was performed on the collected data. The results obtained indicated a significant decrease in serum levels of BUN and a significant increase in serum levels of AST, ALT, ALP, T. protein, T. Bilirubin, and D. Bilirubin. The results also indicated a highly significant increase in serum levels of triglycerides and VLDL, and a highly significant decrease in HDL levels for patients group when compared with control. The present study concluded that there is a clear relationship between disturbances of liver function and the promotion of acute pancreatitis. Therefore, we can suggest that liver enzymes (AST, ALT, and ALP) are good indicators for pursing acute pancreatitis. Additionally, the results confirm that triglycerides, HDL, and VLDL may be helpful in identifying patients at risk of acute pancreatitis.