2-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-(4-hydroxyphenyl) -2-methyl-3-oxo-1-thia-4-aza-spiro[4.5]decan-4-yl]acetamide ethanol disolvate

Abstract

In the title compound, C28H27BrN4O 3S2·2C2H6O, the cyclohexane ring adopts a chair conformation. The imidazo[2,1-b][1,3]thiazole ring system is essentially planar with a dihedral angle of 1.1 (2)°between the thiazole and imidazole rings. The mean plane of this ring system makes dihedral angles of 8.11 (16) and 79.43 (17)°, respectively, with the bromo- and hydroxy-substituted benzene rings. In the 5-methyl-1,3-thiazolidin-4-one group, the S atom, the methyl group and the ring C atoms bonded to them are disordered over two sets of sites with refined occupancies of 0.610 (19) and 0.390 (19). The crystal structure features N - H⋯O, O - H⋯O, O - H⋯N and C - H⋯O hydrogen bonds and C - H⋯π inter-actions. Furthermore, two weak π-π stacking inter-actions [centroid-centroid distances = 3.967 (3) and 3.892 (2) Å] are also observed. © Akkurt et al. 2012.