Retraction Note to: Associations of IL-8 gene polymorphisms and IL-8 levels with predisposition to age-related macular degeneration: a meta-analysis

Abstract

Purpose: Interleukin-8 (IL-8) might influence predisposition to age-related macular degeneration (AMD), but the results of related studies were still controversial and ambiguous. The authors designed this meta-analysis to more precisely estimate the relationships between IL-8 gene polymorphisms, IL-8 levels, and predisposition to AMD. Methods: Meta-analyses of studies that investigated IL-8 gene polymorphisms and IL-8 levels in patients with AMD and controls were performed. Results: The pooled meta-analyses result showed that IL-8 +781 C/T (rs2227306) polymorphism was significantly associated with predisposition to AMD and wet AMD, but no such significant association was detected for IL-8 −251 A/T (rs4073) polymorphism. In parallel, we also found that patients with AMD or wet AMD had elevated IL-8 levels compared to controls. Conclusions: This meta-analysis suggests that IL-8 +781 C/T polymorphism affects predisposition to AMD and wet AMD. Moreover, patients with AMD and wet AMD also have elevated IL-8 levels.