Effect of Raphanus sativus on Glucose, Cholesterol and Triglycerides Levels in Glucose Loaded Rats

Abstract

Background: Diabetes is now a serious health concern, and the import of medications from other countries consumes a significant amount of foreign cash each year. The effects of Raphanus satives (Radish) in the treatment of diabetes mellitus were evaluated scientifically in this study. Thyroid hormone increases metabolic actions in almost every tissue, and the current study was an attempt to evaluate scientifically the effects of R. satives in the treatment of diabetes mellitus. Objectives: The main objective of this study is to evaluate the hypoglycemic effect of R. sativus on induced hyperglycemic rats. Methods: An oral administration of ethanolic extract of R. sativus in glucose loaded rats at dose of 250mg/k body weight, standard group was administered with 10mg/kg of hypoglycemic drug glibenclamide for 2 consecutive weeks. The control group was given distilled water only. After the two weeks' time, the groups were subjected to a glucose tolerance test and measurement of plasma cholesterol and triglyceride levels. Results: Significant reduction of blood glucose was observed (P <0.001), when compared with the control group at 2 hours after glucose loud. Radish ethanolic extract did not present any significant difference in cholesterol level after 2 weeks compared with start point. No significant difference was seen in triglyceride level after 2 weeks of administration of Radish extract compared with start point. Radish extract (250 mg/kg) did not affect kidney function creatinin and urea, also liver function was not affected. In addition, Glutamic-Oxaloacetic Transaminase (GOT), Glutamic-Pyruvate Transaminase (GPT), albumin, and total protein and bilirubin were not affected, meaning that administration of increased doses to hyperglycemic subjects can be considered safe. Conclusion: In this investigation, doses of radish extract (250 mg/kg) had no effect on renal function, creatinin, and urea, as well as liver function. There was also no effect on Glutamic-Oxaloacetic Transaminase (GOT), Glutamic-Pyruvate Transaminase (GPT), albumin, total protein, and bilirubin.